RAI1-PEMT Fusion FISH Probe
The RAI1-PEMT Fusion FISH Probe is used to confirm a fusion of the RAI1 and PEMT genes. The fusion of the RAI1 and PEMT genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAI1-PEMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-RERE | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-REOR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-REGO | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-REGR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-REAQ | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-ORRE | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-OROR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-ORGO | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GORE | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GOOR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GOGO | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GOGR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GRRE | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GROR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GRGO | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GRGR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-AQRE | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-AQOR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-AQGO | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-AQGR | 20 (40 μL) | 200 μL |
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| RAI1-PEMT-20-AQAQ | 20 (40 μL) | 200 μL |
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PEMT Gene Summary
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Gene Name: Phosphatidylethanolamine N-methyltransferase
Chromosome: CHR17: 17408876 -17494994
Locus: 17p11.2
RAI1 Gene Summary
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. [provided by RefSeq, Jul 2008]
Gene Name: Retinoic Acid Induced 1
Chromosome: CHR17: 17584786 -17714765
Locus: 17p11.2
Gene Diseases
The RAI1 PEMT Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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