RAF1-XPC Fusion FISH Probe
The RAF1-XPC Fusion FISH Probe is used to confirm a fusion of the RAF1 and XPC genes. The fusion of the RAF1 and XPC genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAF1-XPC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-RERE | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-REOR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-REGO | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-REGR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-REAQ | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-ORRE | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-OROR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-ORGO | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GORE | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GOOR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GOGO | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GOGR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GRRE | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GROR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GRGO | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GRGR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-AQRE | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-AQOR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-AQGO | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-AQGR | 20 (40 μL) | 200 μL |
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| RAF1-XPC-20-AQAQ | 20 (40 μL) | 200 μL |
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RAF1 Gene Summary
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Name: Raf-1 Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR3: 12625099 -12705700
Locus: 3p25.2
XPC Gene Summary
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Gene Name: XPC Complex Subunit, DNA Damage Recognition And Repair Factor
Chromosome: CHR3: 14186647 -14220172
Locus: 3p25.1
Gene Diseases
The RAF1 XPC Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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