RAF1-PHC3 Fusion FISH Probe
The RAF1-PHC3 Fusion FISH Probe is used to confirm a fusion of the RAF1 and PHC3 genes. The fusion of the RAF1 and PHC3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAF1-PHC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-RERE | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-REOR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-REGO | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-REGR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-REAQ | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-ORRE | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-OROR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-ORGO | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GORE | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GOOR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GOGO | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GOGR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GRRE | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GROR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GRGO | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GRGR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-AQRE | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-AQOR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-AQGO | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-AQGR | 20 (40 μL) | 200 μL |
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| RAF1-PHC3-20-AQAQ | 20 (40 μL) | 200 μL |
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RAF1 Gene Summary
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Name: Raf-1 Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR3: 12625099 -12705700
Locus: 3p25.2
PHC3 Gene Summary
The Polyhomeotic Homolog 3 (PHC3) gene is located on chr3 :169805367-169899537 at 3q26.2.
Gene Name: Polyhomeotic Homolog 3
Chromosome: CHR3: 169805367 -169899537
Locus: 3q26.2
Gene Diseases
The RAF1 PHC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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