RAD50-SLC22A4 Fusion FISH Probe
The RAD50-SLC22A4 Fusion FISH Probe is used to confirm a fusion of the RAD50 and SLC22A4 genes. The fusion of the RAD50 and SLC22A4 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD50-SLC22A4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-RERE | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-REOR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-REGO | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-REGR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-OROR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GORE | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GROR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD50-SLC22A4-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC22A4 Gene Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Gene Name: Solute Carrier Family 22 Member 4
Chromosome: CHR5: 131630144 -131679899
Locus: 5q31.1
RAD50 Gene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
Gene Name: RAD50 Double Strand Break Repair Protein
Chromosome: CHR5: 131892615 -131980313
Locus: 5q31.1
Gene Diseases
The RAD50 SLC22A4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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