RAD50-CADPS Fusion FISH Probe
The RAD50-CADPS Fusion FISH Probe is used to confirm a fusion of the RAD50 and CADPS genes. The fusion of the RAD50 and CADPS genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD50-CADPS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-RERE | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-REOR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-REGO | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-REGR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-OROR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GORE | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GROR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD50-CADPS-20-AQAQ | 20 (40 μL) | 200 μL |
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CADPS Gene Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Gene Name: Calcium Dependent Secretion Activator
Chromosome: CHR3: 62384020 -62861064
Locus: 3p14.2
RAD50 Gene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
Gene Name: RAD50 Double Strand Break Repair Protein
Chromosome: CHR5: 131892615 -131980313
Locus: 5q31.1
Gene Diseases
The RAD50 CADPS Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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