RAD18-CD86 Fusion FISH Probe
The RAD18-CD86 Fusion FISH Probe is used to confirm a fusion of the RAD18 and CD86 genes. The fusion of the RAD18 and CD86 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD18-CD86-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-RERE | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-REOR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-REGO | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-REGR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-OROR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GORE | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GROR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD18-CD86-20-AQAQ | 20 (40 μL) | 200 μL |
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CD86 Gene Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Gene Name: CD86 Molecule
Chromosome: CHR3: 121774208 -121839988
Locus: 3q13.33
RAD18 Gene Summary
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Name: RAD18, E3 Ubiquitin Protein Ligase
Chromosome: CHR3: 8918879 -9005159
Locus: 3p25.3
Gene Diseases
The RAD18 CD86 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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