RAD17-CNTN5 Fusion FISH Probe
The RAD17-CNTN5 Fusion FISH Probe is used to confirm a fusion of the RAD17 and CNTN5 genes. The fusion of the RAD17 and CNTN5 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD17-CNTN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-RERE | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-REOR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-REGO | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-REGR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-REAQ | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-ORRE | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-OROR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-ORGO | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GORE | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GOOR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GOGO | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GROR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GRGR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-AQRE | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-AQGO | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-AQGR | 20 (40 μL) | 200 μL |
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| RAD17-CNTN5-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD17 Gene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Name: RAD17 Checkpoint Clamp Loader Component
Chromosome: CHR5: 68665123 -68710630
Locus: 5q13.2
CNTN5 Gene Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Contactin 5
Chromosome: CHR11: 98891705 -100229616
Locus: 11q22.1
Gene Diseases
The RAD17 CNTN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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