RAB6A-MRPL48 Fusion FISH Probe
The RAB6A-MRPL48 Fusion FISH Probe is used to confirm a fusion of the RAB6A and MRPL48 genes. The fusion of the RAB6A and MRPL48 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB6A-MRPL48-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-RERE | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-REOR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-REGO | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-REGR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-OROR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GORE | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GROR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB6A-MRPL48-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB6A Gene Summary
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: RAB6A, Member RAS Oncogene Family
Chromosome: CHR11: 73386682 -73472201
Locus: 11q13.4
MRPL48 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Mitochondrial Ribosomal Protein L48
Chromosome: CHR11: 73498916 -73575656
Locus: 11q13.4
Gene Diseases
The RAB6A MRPL48 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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