RAB6A-MICA Fusion FISH Probe
The RAB6A-MICA Fusion FISH Probe is used to confirm a fusion of the RAB6A and MICA genes. The fusion of the RAB6A and MICA genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAB6A-MICA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-RERE | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-REOR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-REGO | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-REGR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-REAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-ORRE | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-OROR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-ORGO | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GORE | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GOOR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GOGO | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GOGR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GRRE | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GROR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GRGO | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GRGR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-AQRE | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-AQOR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-AQGO | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-AQGR | 20 (40 μL) | 200 μL |
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| RAB6A-MICA-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB6A Gene Summary
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: RAB6A, Member RAS Oncogene Family
Chromosome: CHR11: 73386682 -73472201
Locus: 11q13.4
MICA Gene Summary
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: MHC Class I Polypeptide-related Sequence A
Chromosome: CHR6_qbl_hap6: 2661006 -2676580
Locus: 6p21.33
Gene Diseases
The RAB6A MICA Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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