PYGL-TRIM9 Fusion FISH Probe
The PYGL-TRIM9 Fusion FISH Probe is used to confirm a fusion of the PYGL and TRIM9 genes. The fusion of the PYGL and TRIM9 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PYGL-TRIM9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-RERE | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-REOR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-REGO | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-REGR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-REAQ | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-ORRE | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-OROR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-ORGO | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-ORAQ | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GORE | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GOOR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GOGO | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GOGR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GOAQ | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GRRE | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GROR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GRGO | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GRGR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-GRAQ | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-AQRE | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-AQOR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-AQGO | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-AQGR | 20 (40 μL) | 200 μL |
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| PYGL-TRIM9-20-AQAQ | 20 (40 μL) | 200 μL |
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PYGL Gene Summary
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
Gene Name: Glycogen Phosphorylase L
Chromosome: CHR14: 51371934 -51411248
Locus: 14q22.1
TRIM9 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Tripartite Motif Containing 9
Chromosome: CHR14: 51441980 -51562422
Locus: 14q22.1
Gene Diseases
The PYGL TRIM9 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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