PVR-SIRT2 Fusion FISH Probe
The PVR-SIRT2 Fusion FISH Probe is used to confirm a fusion of the PVR and SIRT2 genes. The fusion of the PVR and SIRT2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PVR-SIRT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-RERE | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-REOR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-REGO | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-REGR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-REAQ | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-ORRE | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-OROR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-ORGO | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GORE | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GOOR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GOGO | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GOGR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GRRE | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GROR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GRGO | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GRGR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-AQRE | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-AQOR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-AQGO | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-AQGR | 20 (40 μL) | 200 μL |
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| PVR-SIRT2-20-AQAQ | 20 (40 μL) | 200 μL |
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PVR Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Poliovirus Receptor
Chromosome: CHR19: 45147097 -45169428
Locus: 19q13.31
SIRT2 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Gene Name: Sirtuin 2
Chromosome: CHR19: 39369194 -39390502
Locus: 19q13.2
Gene Diseases
The PVR SIRT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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