PVR-HPN Fusion FISH Probe
The PVR-HPN Fusion FISH Probe is used to confirm a fusion of the PVR and HPN genes. The fusion of the PVR and HPN genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PVR-HPN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-RERE | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-REOR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-REGO | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-REGR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-REAQ | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-ORRE | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-OROR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-ORGO | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GORE | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GOOR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GOGO | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GOGR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GRRE | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GROR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GRGO | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GRGR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-AQRE | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-AQOR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-AQGO | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-AQGR | 20 (40 μL) | 200 μL |
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| PVR-HPN-20-AQAQ | 20 (40 μL) | 200 μL |
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HPN Gene Summary
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: Hepsin
Chromosome: CHR19: 35531409 -35557477
Locus: 19q13.11
PVR Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Poliovirus Receptor
Chromosome: CHR19: 45147097 -45169428
Locus: 19q13.31
Gene Diseases
The PVR HPN Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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