PUM1-YARS Fusion FISH Probe
The PUM1-YARS Fusion FISH Probe is used to confirm a fusion of the PUM1 and YARS genes. The fusion of the PUM1 and YARS genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PUM1-YARS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-RERE | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-REOR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-REGO | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-REGR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-REAQ | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-ORRE | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-OROR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-ORGO | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-ORAQ | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GORE | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GOOR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GOGO | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GOGR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GOAQ | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GRRE | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GROR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GRGO | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GRGR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-GRAQ | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-AQRE | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-AQOR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-AQGO | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-AQGR | 20 (40 μL) | 200 μL |
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| PUM1-YARS-20-AQAQ | 20 (40 μL) | 200 μL |
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YARS Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosyl-tRNA Synthetase
Chromosome: CHR1: 33240839 -33283633
Locus: 1p35.1
PUM1 Gene Summary
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Pumilio RNA Binding Family Member 1
Chromosome: CHR1: 31404352 -31538564
Locus: 1p35.2
Gene Diseases
The PUM1 YARS Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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