PUM1-EIF4G3 Fusion FISH Probe
The PUM1-EIF4G3 Fusion FISH Probe is used to confirm a fusion of the PUM1 and EIF4G3 genes. The fusion of the PUM1 and EIF4G3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PUM1-EIF4G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-RERE | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-REOR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-REGO | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-REGR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-REAQ | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-ORRE | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-OROR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-ORGO | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GORE | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GOOR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GOGO | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GOGR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GRRE | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GROR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GRGO | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GRGR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-AQRE | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-AQOR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-AQGO | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-AQGR | 20 (40 μL) | 200 μL |
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| PUM1-EIF4G3-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
PUM1 Gene Summary
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Pumilio RNA Binding Family Member 1
Chromosome: CHR1: 31404352 -31538564
Locus: 1p35.2
Gene Diseases
The PUM1 EIF4G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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