PTPRZ1-MET Fusion FISH Probe
The PTPRZ1-MET Fusion FISH Probe is used to confirm a fusion of the PTPRZ1 and MET genes. The fusion of the PTPRZ1 and MET genes has been associated with Glioblastoma Multiforme, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRZ1-MET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRZ1-MET-20-AQAQ | 20 (40 μL) | 200 μL |
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MET Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458 -116438440
Locus: 7q31.2
PTPRZ1 Gene Summary
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type Z1
Chromosome: CHR7: 121513158 -121702090
Locus: 7q31.32
Gene Diseases
The PTPRZ1 MET Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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