PTPRU-NOS1AP Fusion FISH Probe
The PTPRU-NOS1AP Fusion FISH Probe is used to confirm a fusion of the PTPRU and NOS1AP genes. The fusion of the PTPRU and NOS1AP genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRU-NOS1AP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRU-NOS1AP-20-AQAQ | 20 (40 μL) | 200 μL |
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NOS1AP Gene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Name: Nitric Oxide Synthase 1 Adaptor Protein
Chromosome: CHR1: 162039580 -162339813
Locus: 1q23.3
PTPRU Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type U
Chromosome: CHR1: 29563027 -29653325
Locus: 1p35.3
Gene Diseases
The PTPRU NOS1AP Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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