PTPRT-NCOA3 Fusion FISH Probe
The PTPRT-NCOA3 Fusion FISH Probe is used to confirm a fusion of the PTPRT and NCOA3 genes. The fusion of the PTPRT and NCOA3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRT-NCOA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRT-NCOA3-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOA3 Gene Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Gene Name: Nuclear Receptor Coactivator 3
Chromosome: CHR20: 46130600 -46285621
Locus: 20q13.12
PTPRT Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type T
Chromosome: CHR20: 40701391 -41818557
Locus: 20q12-q13.11
Gene Diseases
The PTPRT NCOA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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