PTPRM-ELP4 Fusion FISH Probe
The PTPRM-ELP4 Fusion FISH Probe is used to confirm a fusion of the PTPRM and ELP4 genes. The fusion of the PTPRM and ELP4 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRM-ELP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRM-ELP4-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRM Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type M
Chromosome: CHR18: 7567313 -8406859
Locus: 18p11.23
ELP4 Gene Summary
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: Elongator Acetyltransferase Complex Subunit 4
Chromosome: CHR11: 31531296 -31805329
Locus: 11p13
Gene Diseases
The PTPRM ELP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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