PTPRK-SPARCL1 Fusion FISH Probe
The PTPRK-SPARCL1 Fusion FISH Probe is used to confirm a fusion of the PTPRK and SPARCL1 genes. The fusion of the PTPRK and SPARCL1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRK-SPARCL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRK-SPARCL1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
SPARCL1 Gene Summary
The SPARC Like 1 (SPARCL1) gene is located on chr4 :88394487-88450655 at 4q22.1.
Gene Name: SPARC Like 1
Chromosome: CHR4: 88394487 -88450655
Locus: 4q22.1
Gene Diseases
The PTPRK SPARCL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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