PTPRK-SMNDC1 Fusion FISH Probe
The PTPRK-SMNDC1 Fusion FISH Probe is used to confirm a fusion of the PTPRK and SMNDC1 genes. The fusion of the PTPRK and SMNDC1 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRK-SMNDC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRK-SMNDC1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
SMNDC1 Gene Summary
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]
Gene Name: Survival Motor Neuron Domain Containing 1
Chromosome: CHR10: 112052797 -112064707
Locus: 10q25.2
Gene Diseases
The PTPRK SMNDC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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