PTPRK-RSPO3 Fusion FISH Probe
The PTPRK-RSPO3 Fusion FISH Probe is used to confirm a fusion of the PTPRK and RSPO3 genes. The fusion of the PTPRK and RSPO3 genes has been associated with Rectum Adenocarcinoma, Colon Adenocarcinoma, Colon Adenocarcinoma, Colon Adenocarcinoma, Rectum Adenocarcinoma, Rectum Adenocarcinoma, Esophageal Carcinoma, Colon Adenocarcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPRK-RSPO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PTPRK-RSPO3-20-AQAQ | 20 (40 μL) | 200 μL |
|
PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
RSPO3 Gene Summary
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Gene Name: R-spondin 3
Chromosome: CHR6: 127440047 -127518184
Locus: 6q22.33
Gene Diseases
The PTPRK RSPO3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Rectum Adenocarcinoma |
| Colon Adenocarcinoma |
| Colon Adenocarcinoma |
| Colon Adenocarcinoma |
| Rectum Adenocarcinoma |
| Rectum Adenocarcinoma |
| Esophageal Carcinoma |
| Colon Adenocarcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|