PTPRK-POPDC3 Fusion FISH Probe
The PTPRK-POPDC3 Fusion FISH Probe is used to confirm a fusion of the PTPRK and POPDC3 genes. The fusion of the PTPRK and POPDC3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRK-POPDC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRK-POPDC3-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
POPDC3 Gene Summary
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008]
Gene Name: Popeye Domain Containing 3
Chromosome: CHR6: 105605774 -105627858
Locus: 6q21
Gene Diseases
The PTPRK POPDC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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