PTPRG-MCM3AP Fusion FISH Probe
The PTPRG-MCM3AP Fusion FISH Probe is used to confirm a fusion of the PTPRG and MCM3AP genes. The fusion of the PTPRG and MCM3AP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRG-MCM3AP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRG-MCM3AP-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRG Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type G
Chromosome: CHR3: 61547242 -62280573
Locus: 3p14.2
MCM3AP Gene Summary
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
Gene Name: Minichromosome Maintenance Complex Component 3 Associated Protein
Chromosome: CHR21: 47655047 -47705236
Locus: 21q22.3
Gene Diseases
The PTPRG MCM3AP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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