PTPRG-FHIT Fusion FISH Probe
The PTPRG-FHIT Fusion FISH Probe is used to confirm a fusion of the PTPRG and FHIT genes. The fusion of the PTPRG and FHIT genes has been associated with Skin Cutaneous Melanoma, Liver Hepatocellular Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRG-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRG-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
PTPRG Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type G
Chromosome: CHR3: 61547242 -62280573
Locus: 3p14.2
Gene Diseases
The PTPRG FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Liver Hepatocellular Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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