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PTPRG-FHIT Fusion FISH Probe

The PTPRG-FHIT Fusion FISH Probe is used to confirm a fusion of the PTPRG and FHIT genes. The fusion of the PTPRG and FHIT genes has been associated with Skin Cutaneous Melanoma, Liver Hepatocellular Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPRG-FHIT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPRG-FHIT-20-RERE 20 (40 μL) 200 μL
PTPRG-FHIT-20-REOR 20 (40 μL) 200 μL
PTPRG-FHIT-20-REGO 20 (40 μL) 200 μL
PTPRG-FHIT-20-REGR 20 (40 μL) 200 μL
PTPRG-FHIT-20-REAQ 20 (40 μL) 200 μL
PTPRG-FHIT-20-ORRE 20 (40 μL) 200 μL
PTPRG-FHIT-20-OROR 20 (40 μL) 200 μL
PTPRG-FHIT-20-ORGO 20 (40 μL) 200 μL
PTPRG-FHIT-20-ORAQ 20 (40 μL) 200 μL
PTPRG-FHIT-20-GORE 20 (40 μL) 200 μL
PTPRG-FHIT-20-GOOR 20 (40 μL) 200 μL
PTPRG-FHIT-20-GOGO 20 (40 μL) 200 μL
PTPRG-FHIT-20-GOGR 20 (40 μL) 200 μL
PTPRG-FHIT-20-GOAQ 20 (40 μL) 200 μL
PTPRG-FHIT-20-GRRE 20 (40 μL) 200 μL
PTPRG-FHIT-20-GROR 20 (40 μL) 200 μL
PTPRG-FHIT-20-GRGO 20 (40 μL) 200 μL
PTPRG-FHIT-20-GRGR 20 (40 μL) 200 μL
PTPRG-FHIT-20-GRAQ 20 (40 μL) 200 μL
PTPRG-FHIT-20-AQRE 20 (40 μL) 200 μL
PTPRG-FHIT-20-AQOR 20 (40 μL) 200 μL
PTPRG-FHIT-20-AQGO 20 (40 μL) 200 μL
PTPRG-FHIT-20-AQGR 20 (40 μL) 200 μL
PTPRG-FHIT-20-AQAQ 20 (40 μL) 200 μL

FHIT Gene Summary

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

Gene Name: Fragile Histidine Triad

Chromosome: CHR3: 59735035 -61237133

Locus: 3p14.2

PTPRG Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Receptor Type G

Chromosome: CHR3: 61547242 -62280573

Locus: 3p14.2

Gene Diseases

The PTPRG FHIT Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma
Liver Hepatocellular Carcinoma
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.