PTPRD-IDO1 Fusion FISH Probe
The PTPRD-IDO1 Fusion FISH Probe is used to confirm a fusion of the PTPRD and IDO1 genes. The fusion of the PTPRD and IDO1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPRD-IDO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PTPRD-IDO1-20-AQAQ | 20 (40 μL) | 200 μL |
|
IDO1 Gene Summary
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Gene Name: Indoleamine 2,3-dioxygenase 1
Chromosome: CHR8: 39771327 -39786309
Locus: 8p11.21
PTPRD Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type D
Chromosome: CHR9: 8314245 -10612723
Locus: 9p24.1-p23
Gene Diseases
The PTPRD IDO1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|