PTPRA-TADA2A Fusion FISH Probe
The PTPRA-TADA2A Fusion FISH Probe is used to confirm a fusion of the PTPRA and TADA2A genes. The fusion of the PTPRA and TADA2A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRA-TADA2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRA-TADA2A-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRA Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type A
Chromosome: CHR20: 2844840 -3019315
Locus: 20p13
TADA2A Gene Summary
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Gene Name: Transcriptional Adaptor 2A
Chromosome: CHR17: 35766976 -35837226
Locus: 17q12
Gene Diseases
The PTPRA TADA2A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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