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PTPRA-SUPT16H Fusion FISH Probe

The PTPRA-SUPT16H Fusion FISH Probe is used to confirm a fusion of the PTPRA and SUPT16H genes. The fusion of the PTPRA and SUPT16H genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPRA-SUPT16H-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-RERE 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-REOR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-REGO 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-REGR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-REAQ 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-ORRE 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-OROR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-ORGO 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-ORAQ 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GORE 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GOOR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GOGO 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GOGR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GOAQ 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GRRE 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GROR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GRGO 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GRGR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-GRAQ 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-AQRE 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-AQOR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-AQGO 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-AQGR 20 (40 μL) 200 μL
PTPRA-SUPT16H-20-AQAQ 20 (40 μL) 200 μL

PTPRA Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Receptor Type A

Chromosome: CHR20: 2844840 -3019315

Locus: 20p13

SUPT16H Gene Summary

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit

Chromosome: CHR14: 21819630 -21852425

Locus: 14q11.2

Gene Diseases

The PTPRA SUPT16H Fusion has been associated with the following diseases:

Disease Name
Brain Lower Grade Glioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.