PTPRA-SUPT16H Fusion FISH Probe
The PTPRA-SUPT16H Fusion FISH Probe is used to confirm a fusion of the PTPRA and SUPT16H genes. The fusion of the PTPRA and SUPT16H genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRA-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRA-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRA Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type A
Chromosome: CHR20: 2844840 -3019315
Locus: 20p13
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The PTPRA SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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