PTPRA-PRSS1 Fusion FISH Probe
The PTPRA-PRSS1 Fusion FISH Probe is used to confirm a fusion of the PTPRA and PRSS1 genes. The fusion of the PTPRA and PRSS1 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRA-PRSS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRA-PRSS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRSS1 Gene Summary
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Name: Protease, Serine 1
Chromosome: CHR7: 142457318 -142460927
Locus: 7q34
PTPRA Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type A
Chromosome: CHR20: 2844840 -3019315
Locus: 20p13
Gene Diseases
The PTPRA PRSS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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