PTPRA-CDK5RAP1 Fusion FISH Probe
The PTPRA-CDK5RAP1 Fusion FISH Probe is used to confirm a fusion of the PTPRA and CDK5RAP1 genes. The fusion of the PTPRA and CDK5RAP1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPRA-CDK5RAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPRA-CDK5RAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRA Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type A
Chromosome: CHR20: 2844840 -3019315
Locus: 20p13
CDK5RAP1 Gene Summary
This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Gene Name: CDK5 Regulatory Subunit Associated Protein 1
Chromosome: CHR20: 31946644 -31989337
Locus: 20q11.21
Gene Diseases
The PTPRA CDK5RAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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