PTPN9-SLC12A1 Fusion FISH Probe
The PTPN9-SLC12A1 Fusion FISH Probe is used to confirm a fusion of the PTPN9 and SLC12A1 genes. The fusion of the PTPN9 and SLC12A1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN9-SLC12A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN9-SLC12A1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN9 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 9
Chromosome: CHR15: 75759461 -75871625
Locus: 15q24.2
SLC12A1 Gene Summary
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
Gene Name: Solute Carrier Family 12 Member 1
Chromosome: CHR15: 48498497 -48596275
Locus: 15q21.1
Gene Diseases
The PTPN9 SLC12A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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