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PTPN6-LRRC23 Fusion FISH Probe

The PTPN6-LRRC23 Fusion FISH Probe is used to confirm a fusion of the PTPN6 and LRRC23 genes. The fusion of the PTPN6 and LRRC23 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPN6-LRRC23-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPN6-LRRC23-20-RERE 20 (40 μL) 200 μL
PTPN6-LRRC23-20-REOR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-REGO 20 (40 μL) 200 μL
PTPN6-LRRC23-20-REGR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-REAQ 20 (40 μL) 200 μL
PTPN6-LRRC23-20-ORRE 20 (40 μL) 200 μL
PTPN6-LRRC23-20-OROR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-ORGO 20 (40 μL) 200 μL
PTPN6-LRRC23-20-ORAQ 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GORE 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GOOR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GOGO 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GOGR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GOAQ 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GRRE 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GROR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GRGO 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GRGR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-GRAQ 20 (40 μL) 200 μL
PTPN6-LRRC23-20-AQRE 20 (40 μL) 200 μL
PTPN6-LRRC23-20-AQOR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-AQGO 20 (40 μL) 200 μL
PTPN6-LRRC23-20-AQGR 20 (40 μL) 200 μL
PTPN6-LRRC23-20-AQAQ 20 (40 μL) 200 μL

PTPN6 Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 6

Chromosome: CHR12: 7055739 -7070479

Locus: 12p13.31

LRRC23 Gene Summary

The Leucine Rich Repeat Containing 23 (LRRC23) gene is located on chr12 :7013896-7023406 at 12p13.31.

Gene Name: Leucine Rich Repeat Containing 23

Chromosome: CHR12: 7013896 -7023406

Locus: 12p13.31

Gene Diseases

The PTPN6 LRRC23 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.