PTPN6-LEPREL2 Fusion FISH Probe
The PTPN6-LEPREL2 Fusion FISH Probe is used to confirm a fusion of the PTPN6 and LEPREL2 genes. The fusion of the PTPN6 and LEPREL2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN6-LEPREL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN6-LEPREL2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN6 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 6
Chromosome: CHR12: 7055739 -7070479
Locus: 12p13.31
Gene Diseases
The PTPN6 LEPREL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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