PTPN4-LCT Fusion FISH Probe
The PTPN4-LCT Fusion FISH Probe is used to confirm a fusion of the PTPN4 and LCT genes. The fusion of the PTPN4 and LCT genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN4-LCT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN4-LCT-20-AQAQ | 20 (40 μL) | 200 μL |
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LCT Gene Summary
The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. [provided by RefSeq, Jan 2016]
Gene Name: Lactase
Chromosome: CHR2: 136545414 -136594750
Locus: 2q21.3
PTPN4 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 4
Chromosome: CHR2: 120517206 -120735037
Locus: 2q14.2
Gene Diseases
The PTPN4 LCT Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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