PTPN3-ASTN2 Fusion FISH Probe
The PTPN3-ASTN2 Fusion FISH Probe is used to confirm a fusion of the PTPN3 and ASTN2 genes. The fusion of the PTPN3 and ASTN2 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN3-ASTN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN3-ASTN2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN3 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 3
Chromosome: CHR9: 112137973 -112260593
Locus: 9q31.3
ASTN2 Gene Summary
This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Gene Name: Astrotactin 2
Chromosome: CHR9: 119187503 -120177317
Locus: 9q33.1
Gene Diseases
The PTPN3 ASTN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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