PTPN21-TTC8 Fusion FISH Probe
The PTPN21-TTC8 Fusion FISH Probe is used to confirm a fusion of the PTPN21 and TTC8 genes. The fusion of the PTPN21 and TTC8 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN21-TTC8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN21-TTC8-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN21 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 21
Chromosome: CHR14: 88932121 -89021123
Locus: 14q31.3
TTC8 Gene Summary
This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. A mutation in this gene has also been implicated in nonsyndromic retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Tetratricopeptide Repeat Domain 8
Chromosome: CHR14: 89290977 -89344335
Locus: 14q31.3
Gene Diseases
The PTPN21 TTC8 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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