PTPN2-MYL12B Fusion FISH Probe
The PTPN2-MYL12B Fusion FISH Probe is used to confirm a fusion of the PTPN2 and MYL12B genes. The fusion of the PTPN2 and MYL12B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN2-MYL12B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN2-MYL12B-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN2 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 2
Chromosome: CHR18: 12785476 -12884334
Locus: 18p11.21
MYL12B Gene Summary
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Gene Name: Myosin Light Chain 12B
Chromosome: CHR18: 3262110 -3278282
Locus: 18p11.31
Gene Diseases
The PTPN2 MYL12B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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