PTPN14-NSL1 Fusion FISH Probe
The PTPN14-NSL1 Fusion FISH Probe is used to confirm a fusion of the PTPN14 and NSL1 genes. The fusion of the PTPN14 and NSL1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN14-NSL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN14-NSL1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN14 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 14
Chromosome: CHR1: 214522038 -214725024
Locus: 1q32.3-q41
NSL1 Gene Summary
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Gene Name: NSL1, MIS12 Kinetochore Complex Component
Chromosome: CHR1: 212899494 -212965139
Locus: 1q32.3
Gene Diseases
The PTPN14 NSL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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