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PTPN13-MAPK10 Fusion FISH Probe

The PTPN13-MAPK10 Fusion FISH Probe is used to confirm a fusion of the PTPN13 and MAPK10 genes. The fusion of the PTPN13 and MAPK10 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPN13-MAPK10-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPN13-MAPK10-20-RERE 20 (40 μL) 200 μL
PTPN13-MAPK10-20-REOR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-REGO 20 (40 μL) 200 μL
PTPN13-MAPK10-20-REGR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-REAQ 20 (40 μL) 200 μL
PTPN13-MAPK10-20-ORRE 20 (40 μL) 200 μL
PTPN13-MAPK10-20-OROR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-ORGO 20 (40 μL) 200 μL
PTPN13-MAPK10-20-ORAQ 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GORE 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GOOR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GOGO 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GOGR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GOAQ 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GRRE 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GROR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GRGO 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GRGR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-GRAQ 20 (40 μL) 200 μL
PTPN13-MAPK10-20-AQRE 20 (40 μL) 200 μL
PTPN13-MAPK10-20-AQOR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-AQGO 20 (40 μL) 200 μL
PTPN13-MAPK10-20-AQGR 20 (40 μL) 200 μL
PTPN13-MAPK10-20-AQAQ 20 (40 μL) 200 μL

MAPK10 Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Gene Name: Mitogen-activated Protein Kinase 10

Chromosome: CHR4: 86936275 -87374283

Locus: 4q21.3

PTPN13 Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 13

Chromosome: CHR4: 87515467 -87736328

Locus: 4q21.3

Gene Diseases

The PTPN13 MAPK10 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.