PTPN12-DYNC1I1 Fusion FISH Probe
The PTPN12-DYNC1I1 Fusion FISH Probe is used to confirm a fusion of the PTPN12 and DYNC1I1 genes. The fusion of the PTPN12 and DYNC1I1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN12-DYNC1I1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN12-DYNC1I1-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNC1I1 Gene Summary
The Dynein Cytoplasmic 1 Intermediate Chain 1 (DYNC1I1) gene is located on chr7 :95401817-95727736 at 7q21.3.
Gene Name: Dynein Cytoplasmic 1 Intermediate Chain 1
Chromosome: CHR7: 95401817 -95727736
Locus: 7q21.3
PTPN12 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 12
Chromosome: CHR7: 77166772 -77269388
Locus: 7q11.23
Gene Diseases
The PTPN12 DYNC1I1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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