PTPN11-PLAGL1 Fusion FISH Probe
The PTPN11-PLAGL1 Fusion FISH Probe is used to confirm a fusion of the PTPN11 and PLAGL1 genes. The fusion of the PTPN11 and PLAGL1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN11-PLAGL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN11-PLAGL1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAGL1 Gene Summary
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Gene Name: PLAG1 Like Zinc Finger 1
Chromosome: CHR6: 144261436 -144385735
Locus: 6q24.2
PTPN11 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 11
Chromosome: CHR12: 112856535 -112947717
Locus: 12q24.13
Gene Diseases
The PTPN11 PLAGL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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