PTPN11-EPYC Fusion FISH Probe
The PTPN11-EPYC Fusion FISH Probe is used to confirm a fusion of the PTPN11 and EPYC genes. The fusion of the PTPN11 and EPYC genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN11-EPYC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN11-EPYC-20-AQAQ | 20 (40 μL) | 200 μL |
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EPYC Gene Summary
Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]
Gene Name: Epiphycan
Chromosome: CHR12: 91357455 -91398803
Locus: 12q21.33
PTPN11 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 11
Chromosome: CHR12: 112856535 -112947717
Locus: 12q24.13
Gene Diseases
The PTPN11 EPYC Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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