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PTPN11-EPYC Fusion FISH Probe

The PTPN11-EPYC Fusion FISH Probe is used to confirm a fusion of the PTPN11 and EPYC genes. The fusion of the PTPN11 and EPYC genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PTPN11-EPYC-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PTPN11-EPYC-20-RERE 20 (40 μL) 200 μL
PTPN11-EPYC-20-REOR 20 (40 μL) 200 μL
PTPN11-EPYC-20-REGO 20 (40 μL) 200 μL
PTPN11-EPYC-20-REGR 20 (40 μL) 200 μL
PTPN11-EPYC-20-REAQ 20 (40 μL) 200 μL
PTPN11-EPYC-20-ORRE 20 (40 μL) 200 μL
PTPN11-EPYC-20-OROR 20 (40 μL) 200 μL
PTPN11-EPYC-20-ORGO 20 (40 μL) 200 μL
PTPN11-EPYC-20-ORAQ 20 (40 μL) 200 μL
PTPN11-EPYC-20-GORE 20 (40 μL) 200 μL
PTPN11-EPYC-20-GOOR 20 (40 μL) 200 μL
PTPN11-EPYC-20-GOGO 20 (40 μL) 200 μL
PTPN11-EPYC-20-GOGR 20 (40 μL) 200 μL
PTPN11-EPYC-20-GOAQ 20 (40 μL) 200 μL
PTPN11-EPYC-20-GRRE 20 (40 μL) 200 μL
PTPN11-EPYC-20-GROR 20 (40 μL) 200 μL
PTPN11-EPYC-20-GRGO 20 (40 μL) 200 μL
PTPN11-EPYC-20-GRGR 20 (40 μL) 200 μL
PTPN11-EPYC-20-GRAQ 20 (40 μL) 200 μL
PTPN11-EPYC-20-AQRE 20 (40 μL) 200 μL
PTPN11-EPYC-20-AQOR 20 (40 μL) 200 μL
PTPN11-EPYC-20-AQGO 20 (40 μL) 200 μL
PTPN11-EPYC-20-AQGR 20 (40 μL) 200 μL
PTPN11-EPYC-20-AQAQ 20 (40 μL) 200 μL

EPYC Gene Summary

Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]

Gene Name: Epiphycan

Chromosome: CHR12: 91357455 -91398803

Locus: 12q21.33

PTPN11 Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 11

Chromosome: CHR12: 112856535 -112947717

Locus: 12q24.13

Gene Diseases

The PTPN11 EPYC Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.