PTPN11-CUX2 Fusion FISH Probe
The PTPN11-CUX2 Fusion FISH Probe is used to confirm a fusion of the PTPN11 and CUX2 genes. The fusion of the PTPN11 and CUX2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN11-CUX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN11-CUX2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN11 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 11
Chromosome: CHR12: 112856535 -112947717
Locus: 12q24.13
CUX2 Gene Summary
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
Gene Name: Cut Like Homeobox 2
Chromosome: CHR12: 111471827 -111788358
Locus: 12q24.11-q24.12
Gene Diseases
The PTPN11 CUX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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