PTPN1-P2RX4 Fusion FISH Probe
The PTPN1-P2RX4 Fusion FISH Probe is used to confirm a fusion of the PTPN1 and P2RX4 genes. The fusion of the PTPN1 and P2RX4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN1-P2RX4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-RERE | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-REOR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-REGR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-REAQ | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-ORRE | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-OROR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-ORGO | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GOOR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GOGO | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GRGR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-AQRE | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-AQGO | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-AQGR | 20 (40 μL) | 200 μL |
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| PTPN1-P2RX4-20-AQAQ | 20 (40 μL) | 200 μL |
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P2RX4 Gene Summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Purinergic Receptor P2X 4
Chromosome: CHR12: 121647663 -121671909
Locus: 12q24.31
PTPN1 Gene Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 1
Chromosome: CHR20: 49126890 -49201086
Locus: 20q13.13
Gene Diseases
The PTPN1 P2RX4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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