PTP4A2-ARFGEF2 Fusion FISH Probe
The PTP4A2-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the PTP4A2 and ARFGEF2 genes. The fusion of the PTP4A2 and ARFGEF2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTP4A2-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| PTP4A2-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTP4A2 Gene Summary
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Gene Name: Protein Tyrosine Phosphatase Type IVA, Member 2
Chromosome: CHR1: 32372021 -32403988
Locus: 1p35.2
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The PTP4A2 ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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