PTK2B-SLC5A1 Fusion FISH Probe
The PTK2B-SLC5A1 Fusion FISH Probe is used to confirm a fusion of the PTK2B and SLC5A1 genes. The fusion of the PTK2B and SLC5A1 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTK2B-SLC5A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-RERE | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-REOR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-REGO | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-REGR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-REAQ | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-ORRE | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-OROR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-ORGO | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GORE | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GOOR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GOGO | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GOGR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GRRE | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GROR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GRGO | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GRGR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-AQRE | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-AQOR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-AQGO | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-AQGR | 20 (40 μL) | 200 μL |
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| PTK2B-SLC5A1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTK2B Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Kinase 2 Beta
Chromosome: CHR8: 27168998 -27316908
Locus: 8p21.2
SLC5A1 Gene Summary
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Solute Carrier Family 5 Member 1
Chromosome: CHR22: 32439018 -32509011
Locus: 22q12.3
Gene Diseases
The PTK2B SLC5A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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