PTK2-UBE2H Fusion FISH Probe
The PTK2-UBE2H Fusion FISH Probe is used to confirm a fusion of the PTK2 and UBE2H genes. The fusion of the PTK2 and UBE2H genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTK2-UBE2H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-RERE | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-REOR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-REGO | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-REGR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-REAQ | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-ORRE | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-OROR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-ORGO | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GORE | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GOOR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GOGO | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GOGR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GRRE | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GROR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GRGO | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GRGR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-AQRE | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-AQOR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-AQGO | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-AQGR | 20 (40 μL) | 200 μL |
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| PTK2-UBE2H-20-AQAQ | 20 (40 μL) | 200 μL |
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PTK2 Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Protein Tyrosine Kinase 2
Chromosome: CHR8: 141668480 -142011412
Locus: 8q24.3
UBE2H Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Gene Name: Ubiquitin Conjugating Enzyme E2 H
Chromosome: CHR7: 129470572 -129592800
Locus: 7q32.2
Gene Diseases
The PTK2 UBE2H Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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