PTK2-RNF139 Fusion FISH Probe
The PTK2-RNF139 Fusion FISH Probe is used to confirm a fusion of the PTK2 and RNF139 genes. The fusion of the PTK2 and RNF139 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTK2-RNF139-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-RERE | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-REOR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-REGO | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-REGR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-REAQ | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-ORRE | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-OROR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-ORGO | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GORE | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GOOR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GOGO | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GOGR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GRRE | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GROR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GRGO | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GRGR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-AQRE | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-AQOR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-AQGO | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-AQGR | 20 (40 μL) | 200 μL |
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| PTK2-RNF139-20-AQAQ | 20 (40 μL) | 200 μL |
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PTK2 Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: Protein Tyrosine Kinase 2
Chromosome: CHR8: 141668480 -142011412
Locus: 8q24.3
RNF139 Gene Summary
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 139
Chromosome: CHR8: 125487007 -125500859
Locus: 8q24.13
Gene Diseases
The PTK2 RNF139 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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