PTGIS-IFT52 Fusion FISH Probe
The PTGIS-IFT52 Fusion FISH Probe is used to confirm a fusion of the PTGIS and IFT52 genes. The fusion of the PTGIS and IFT52 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTGIS-IFT52-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-RERE | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-REOR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-REGO | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-REGR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-REAQ | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-ORRE | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-OROR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-ORGO | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GORE | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GOOR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GOGO | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GOGR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GRRE | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GROR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GRGO | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GRGR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-AQRE | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-AQOR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-AQGO | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-AQGR | 20 (40 μL) | 200 μL |
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| PTGIS-IFT52-20-AQAQ | 20 (40 μL) | 200 μL |
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PTGIS Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Prostaglandin I2 Synthase
Chromosome: CHR20: 48120410 -48184707
Locus: 20q13.13
IFT52 Gene Summary
This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. [provided by RefSeq, Oct 2016]
Gene Name: Intraflagellar Transport 52
Chromosome: CHR20: 42219578 -42275862
Locus: 20q13.12
Gene Diseases
The PTGIS IFT52 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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