PTGES3-NACA Fusion FISH Probe
The PTGES3-NACA Fusion FISH Probe is used to confirm a fusion of the PTGES3 and NACA genes. The fusion of the PTGES3 and NACA genes has been associated with Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTGES3-NACA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PTGES3-NACA-20-AQAQ | 20 (40 μL) | 200 μL |
|
NACA Gene Summary
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]
Gene Name: Nascent Polypeptide-associated Complex Alpha Subunit
Chromosome: CHR12: 57106210 -57119326
Locus: 12q13.3
PTGES3 Gene Summary
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
Gene Name: Prostaglandin E Synthase 3
Chromosome: CHR12: 57057124 -57082078
Locus: 12
Gene Diseases
The PTGES3 NACA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|