PTGES2-DENND1A Fusion FISH Probe
The PTGES2-DENND1A Fusion FISH Probe is used to confirm a fusion of the PTGES2 and DENND1A genes. The fusion of the PTGES2 and DENND1A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTGES2-DENND1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-RERE | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-REOR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-REGO | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-REGR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-REAQ | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-ORRE | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-OROR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-ORGO | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GORE | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GOOR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GOGO | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GOGR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GRRE | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GROR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GRGO | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GRGR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-AQRE | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-AQOR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-AQGO | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-AQGR | 20 (40 μL) | 200 μL |
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| PTGES2-DENND1A-20-AQAQ | 20 (40 μL) | 200 μL |
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DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
PTGES2 Gene Summary
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Name: Prostaglandin E Synthase 2
Chromosome: CHR9: 130882971 -130890712
Locus: 9q34.11
Gene Diseases
The PTGES2 DENND1A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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